My "universal" loadout, i.e., the one I use almost everywhere, is:

Chaos Cowl
Chaos Cloak
Swiftstrike Buckler
Penta x2
Barbarous Thorn Blade
Valiance
Voltedge
Acheron/GF
MSI Med Sprite Perk

I swap Acheron and GF around depending on the situtation.
Not that I'm using Chaos because it's overpowered, but compared to my other choices, it's my best armour. If I had the Grey Feather Set, I'd most certainly use that instead, however I don't, so Chaos it is. I'd also probably use Divine Veil + Skolver Coat if I had any Skolver armour, but again, I don't, so Chaos it is.

The Loadout is saved as "All" for two reasons, one in that the loadout starting with an 'A' puts it at the top of my loadout list for easy access, and two being that it has all four damage types and can be used everywhere.

For absolutely everywhere, I use the Chaos + BKC armor set, Swiftstriker Buckler, +2 CTR and +2 DMG trinkets for the main weapons I'm using, and +2 ASI Battle Sprite Perk from my Lv 100 Maskeraith. I only get killed in C42, HoI, and GA (Grinchlin Assault), so I say it's pretty awesome.

With UVs and bonuses, I stand having...

DMG, ASI, and CTR Max (DMG and ASI Ultra + CTR VH on weapons in slot 4)
MSI Low.
Some freeze resistance.
Some fire and shock weakness.
A lot of poison and curse weakness.
A lot of normal defense, decent amount of elemental defense, and a little amount of shadow defense.

If there's anything I would like to change, it'd be able to get some High ASI UVs on my weapons so I could achieve ASI Max without the perk so I could get MSI High instead (I only have Ultra without the perk). I particularly find maxing your weapon stats (Even going Ultra to Max) to be more important than movement speed increases (except for bombers).

Primary Sword Loadout:

1. Combuster
2. Acheron
3. Barbarous Thorn Blade
4. Argent Peacemaker

Efficient? Yes.
Fun? No.

Desc: It's a very powerful loadout that destroys every single enemy in the clockworks. The two brandishes can easily take on everything on their own, BTB allows for an easier time Vs. Fiends, but can be done without. AP allows for easy turret destruction and defense play; also has the utility of mineral destruction thanks to the clip of 6 bullets. While powerful, it's not that fun due to how easily monsters are destroyed.

Primary Gun Loadout:

1. Nova Driver
2. Umbra Driver
3. Blitz Needle
4. Divine Avenger

Efficient? Yes.
Fun? Yes.

Desc: My most used loadout. The alchemers are very flexible in usage; if combined with two alchemers they can be used for heavy DPS and by themselves they can be used for burst damage. I find them very engaging to use as they require aim to effectively do damage. Nothing is more satisfying than launching one of the charges in between two enemies and destroying them both. It just feels flat out rewarding and fun when you realize that the weapon works only when you properly aim. Blitz is just Blitz, it destroys whatever it wants and doesn't give an eff; very annoying to fight Wolvers with and challenging to fight Fiends with; it's an odd risk/reward feel (though I think the reward is too much...). I haven't used DA much, but it fills it's purpose as shoving enemies off if you get in a tight spot. I guess in a sense it's a good thing I don't use it.

That's a nice armour you have there.

Chaos cowl (I wish i had a Blue Kat Clowak or whatever those are called)
Chaos cloak (because why should you use anything else, really)

Nitronome (Arguably overall usefullest weapon in the game)
DR/Spike Shower (Why not DBB? radiants, bloody radiants)
Some haze bomb (or maybe my Hail Driver if i feel like failing miserably at internal ricochets)

Chaos cowl, vog coat

I use voltedge and acheron for swords

Grey owlite shield

Yep dats it :p

Ps the loadout is called dual brandish

Slow but Semi-Invincible Tank Set:
-Armor=
Ironmight Plate Helm
Ironmight Plate Mail
Ironmight Plate Shield
-Weapons=
Sudaruska (For Knocking things back.)
Voltedge/Callahan
Irontech Destroyer
Iron Slug
-Extra=
Gift of Autumn (Still working on some Pentas without PvP.)
Elite Quick Strike Module (So my Suda and Voltedge aren't so slow as to be useless.)
Seraphynx with Healthy Boost

I use this set mostly in large parties. My job is simple, I survive to the elevator and give minor support with my pet and high knockback weapons while everyone else does most of the killing. If everyone else dies then it will be my job to make it to the next elevator in one piece. When I use this set I not only gain defense, but I must also play defensively. Something many SK players don't seem to understand how to do. Trust me, it works better than people think.

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Gunner with Radioactive Cardboard Armor Set:
-Armor=
Perfect Mask of Seerus
Chaos Cloak
Swiftstrike Buckler
-Weapons=
Callahan/Blitz Needle
Biohazard
Nova Driver/Argent Peacemaker
Fiery Pepperbox/Valiance/Iron Slug (Each for a different kind of utility. Or for fun!)
-Extra=
Elite True Shot Module
Gift of Autumn (Will be replace with Elite Quick Draw in the future.)
Maskeraith with Trueshot II
Military Accessorized Cyclops Helm
Military Accessorized Fencing Jacket

Glass Cannon just isn't the right term for this set. Carboard Nuke is definitely much more fitting. It's fast, it's powerful, I can instant charge almost everything, and I can keep my distance all the time. Whats the catch? Two hits from anything and I'm done. Pop goes the mask, rip goes the cloak, oops! I'm dead. At least I took down a few armies with me.

Whoops

Helm: Dragon Scale Helm
Armor: Snarbolax Coat
Trink: Penta Heart Thing
Trink: Another Penta Heart Thing.
Sword: Gran Faust
Sword: Deadly Candy Poker
Sword: Glacius