As you can see, today i have nothing else to do with my time, but to spam the forums...
Anyway, either a difficulty above Elite or a type of mission where weapons that are ineffective agains a monster family deal no damge whatsoever.
To make it easier lets have split damage still have no effect, i.e: Acheron against gorgo = no damage.
Neutral damge deals weak damage, as if poking a jelly with a flourish.
Effective damge behaves as if it was normal damage.
UVs against specific monster families get a boost and really make the difference here. (Still, Acheron with damage vs fiend very high = no damage)
I think you get the idea.
Amor and shields behave normaly, but take an even greater amount of damge if hit by an attack they are not fit for.