I am running OS X Lion 10.7.5, 2.4 GHz Intel Core 2 Duo, 2 GB RAM, NVIDIA GeForce 320M 256 MB graphics.
When I run a mission through the Missions interface this seems to work fine, but when I tried to enter the Arcade the game sort of just hung at a black screen for a few minutes, refused to close, then finally died out.
I have not had an opportunity to try playing again since this happened but figured I'd post here since I can't access the in-game bug report function currently.