There are a few. These aren't really bugs, as such, but change situations fairly majorly.
First, my game repeatedly crashes. There's probably a memory leak somewhere, as the game breaks 1.5 gb of RAM when it's usually at 500 mb. In order to make sure I don't crash and die when reconnecting, I've been forced to force shut down the process, then restart the game, while sitting in a safe corner.
Second, in the penultimate area of the 16th floor, where you must use the switch to choose your path, you can toss vials to make the bottom route much easier. I'm fairly sure this was not meant to be allowed.
Third, at the boss, both sides can fire their lasers at the same time. Sometimes it's in opposite directions (one moving up, other moving down), and avoidable, but often they will sync up and both fire lasers moving in the same direction, resulting in unavoidable damage.