PROBLEM: A rather strange challenge I find myself tackling is tossing relatively useless pick up items / spamming them to make room for items I want.

The most common scenario is when I end up with a surplus of pickups I generally don't have use for (vials, status orbs) and want to make room for something that dropped recently (pill, remedy mostly). This requires pausing from fighting monsters and just running around spamming the item hot key to use them up really quickly or throwing them away in advance knowing they'll just cause problems later on.

This becomes problematic when I encounter a crucial moment where I am being swarmed and the floor is loaded with pickups that largely don't interest me or are actually ineffective in the scenario I'm in (ie. fire status orbs / fire vials while in a room full of Oilers) and throwing them away also requires some care to not make the situation worse. All when I am burned and there is a remedy sitting somewhere that I can't pick up because there are too many other drops around.

This wasn't so bad when pickups were limited to just vials and the occasional mecha knight, but with the addition of artillery, status orbs, and recon flare (and the inability to throw away items without using them), it's made things worse where danger rooms / arenas are 50/50 fighting monsters and avoiding/tossing pickups.

Basically, I just want to auto-pick up items I always want (pills, remedy) and selectively pick up other items that are situationally useful.

SOLUTION: Set "preferred item slot" gray out options where you reserve a slot for a particular item. Then add a hotkey to allow you to turn this off on the fly to pick up anything nearby (similar to auto-target toggling).