Alchemers, Brandishes, bombs, Divine avenger, etc.
These weapons get better charge attacks. Some like the one you are showing don't. Knowing which ones get better and which don't should affect your decisions when it comes to which weapons to upgrade and which to save for later.
(pity it doesn't get better I like the way the biohazard looks)
What the f...
I knew the difference is high, but I did not know that it is THAT useless. Therefor I do totally regret to upgrade my Catalyzer into a Biohazard (actually still level 3). The loss of CTR is pretty noteable there.
I recommend your first option though: better cancel the damage of a 4* weapon instead of buffing the 5* stuff.