I've been trying to find ways to make the game a bit harder, using personal conduct. One of the best ways I've found so far:

1. Equip exactly as follows, with nothing else:

Pummel Gun
Emberbreak Helm
Frostbreak Armor
No Shield
No alt weapon

Now try and do a T2 run. It should be more evil than anything, but I'm curious to see what people can come up with to make runs hard without being impossible (no weapon/shield solo run, for example, is impossible.)