I started spiral knights recently, so I have little clue how the game works. I had a couple questions.
•What's the best line of guns? Autoguns? Alchemers? Blisters? And is there a specific gun?
•How important is specialized damage?
•Is the nameless set good, or should I aim(no pun intended) for something with a certain resistance?
Have you read the Gunslinger Guide on the wiki? It's not great, but it can help you crystallize your questions.
There is no "best" line of guns. Equipment in this game is not perfectly balanced, but it's not so unbalanced that there's one item that completely outclasses all others. Before this week's massive gunner update, I would have told you to go for Blitz Needle, Umbra Driver, and Nova or Storm Driver. Explaining why takes a while, but it involves doing a lot of damage and using weapons that reward skill. But now I (along with everbody else) am rethinking the handguns.
Specialized damage has a small effect (about 20% extra damage). But if you're carrying multiple guns, then you probably want them to be of distinct specialized types, because you might as well get that extra damage. To learn more, you might read the opening section of my detailed sword guide. The basic ideas are the same for guns as for swords (but not bombs).
Nameless is a good armor, with offensive bonuses and pretty good defense too. Read the Gunslinger Guide. Consider also reading the Armor section of my sword guide, for the basic ideas of how to choose armor. In short, status resistance is more important than damage resistance, and offensive bonuses are even more important than status, once you get advanced enough.