These loadouts are the ones that either I wish to have, or actually have, that I have seen to significantly affect the mobs of which the loadout is based towards. I will have examples of the loadout with 0, 1, and 2 extra weapon slots, and 0, 1, and 2 trinket slots (based on the order of the weapons and the trinkets)
GREMLIN
Helmet: Chaos Cowl
Armor: Vog Cub Coat
Shield: Grey Owlite Shield
Weapon 1: Obsidian Edge (Acheron if necessary)
Weapon 2: Sentenza
Weapon 3: Umbra Driver
Weapon 4: Gran Faust
Trinket 1: Elite Sword Focus Module
Trinket 2: Elite Trueshot Module
Slime
Helmet: Skolver Hood
Armor: Skolver Coat
Shield: Barbarous Thorn Shield
Weapon 1: Obsidian Edge (Acheron if necessary)
Weapon 2: Permafroster
Weapon 3: Divine Avenger
Weapon 4: Senetenza
Trinket 1: Elite Sword Focus Module
Trinket 2: Elite Trueshot Module
FIEND
Helmet: Kat Eye Cowl
Armor: Vog Cub Coat
Shield: Swiftstrike Buckler
Weapon 1: Final Flourish
Weapon 2: Riftlocker
Weapon 3: Hail Driver
Weapon 4: Polaris
Trinket 1: Elite Quick Draw Module
Trinket 2: Elite Trueshot Module
BEAST
Helmet: Skolver Cap
Armor: Skolver Coat
Shield: Barbarous Thorn Shield
Weapon 1: Final Flourish
Weapon 2: Gran Faust
Weapon 3: Riftlocker
Weapon 4: Acheron (or Obsidian Edge)
Trinket 1: Elite Quick Strike Module
Trinket 2: Elite Slash Module
UNDEAD
Helmet: Black Kat Cowl
Armor: Snarbolax Coat
Shield: Crest of Almire
Weapon 1: Voltedge
Weapon 2: Polaris
Weapon 3: Argent Peacemaker
Weapon 4: Electron Vortex
Trinket 1: Elite Sword Focus Module
Trinket 2: Elite Sword Focus Module
CONSTRUCT
Helmet: Chaos Cowl
Armor: Chaos Cloak
Shield: Grey Owlite Shield
Weapon 1: Voltedge
Weapon 2: Polaris
Weapon 3: Divine Avenger
Weapon 4: Hail Driver
Trinket 1: Elite Sword Focus Module
Trinket 2: Elite Trueshot Module
Feel free to tell me any changes you deem fit for this list. I know this is not perfect, so suggestions are appreciated.
Deadly Virulisk is better for slimes.
You beast set has a useless trinket as the armor and shield already give the max buff.
Obsidian edge should be used over the Acheron on all floors but poison themed due to the numerous effects of poison.
Weakened enemy attacks
Lowered enemy defenses
Reversal to all healing factors
FYI I probably wouldn't use these sets since I enjoy being quite status tanky.