I'd personally make a few adjustments, but I like the general idea. Enemies could become 95% transparent, and their bullets would be 90% transparent. They would still make the same noises, so if you can use that to your advantage all the more power to you. I'd say a large circular vignette would surround your screen, be pitch black, and depending on your resistance to the status would be within 4 tiles of your player or upwards of 8 tiles away. Resistance could also affect enemy transparency, making enemies more visible at higher resistances and completely invisible when vulnerable.
I wouldn't make the weapons grant 100% to blind, however I would grant them a good chance of inflicting moderate blind, or perhaps strong blind for the CiV, shard bomb, and graviton.
I like this idea. I want that new stats, at least for monsters. I don't really care if we can inflict it too, but having monster that can would spark new challenge in the game.
When you get blinded the screen get's blacked out and you only see your character and the hud. That would be awesome.