When I play for a bit on high or medium graphics, dropped items (like vials, materials, rarities, etc) will have their icon glitch out. Most of the time it shows the icon repeating in a grid, and moving/turning "moves" the icon in the grid. Light emissions (from lamps and stuff) would also have glitched out light in a similar fashion to the glitched items. Unfortunately I don't have screenshots of the glitched light because they only last for a moment after coming on screen.
https://steamcommunity.com/sharedfiles/filedetails/?id=1591088664
https://steamcommunity.com/sharedfiles/filedetails/?id=1450815707

Yesterday I got a more severe glitch on medium and low (yes low) graphics where everything just stayed on screen until it was "overwritten" by something else. If I turned the graphics to high, the lingering effect would stop but then items and and emissions would glitch again.
https://steamcommunity.com/sharedfiles/filedetails/?id=1592456229
https://steamcommunity.com/sharedfiles/filedetails/?id=1592456248

I have tried reinstalling and it didn't work. Validating game files after the glitch occurs causes it to find several hundred files to reacquire, and playing after that is fine for a bit, but then occurs again after half an hour or so. Validating again causes it to find several hundred files again (not the same number though) to reacquire.

I have an 8700k, RX 580 8GB, and 8x2 3000MHz ram. These problems occur on high and medium, regardless of the other graphics options.