It takes forever, it slows me down a ton, and a doesn't do all that much more damage than a normal attack. In fact, damage-wise, I'm usually better off just hitting the monsters twice with a normal attack.
The only benefit that I can see is that a charged gun shot usually seems to travel farther than a normal gun shot, but that seems to be of limited value.
Some weapons have effect that only happen when charged, and bombs only work when charged