Plate
Movement buffs are supposed to be a major bonus, counterbalanced in Ancient by its enormous health. The lack of specialized defense is assumably compensated by having over ten bars of normal, seeing as there is no visible end to its defense before the full ten bars. It could have twenty normal bars of defense for all we know. The same goes for Volcanic and Ironmight lines. Regardless, my take at this goes for party utility over freelance tactics which nearly everyone uses.
Big Angry and Irontech
Blast lines in general are supposed to be offense based through damage and/or knockback. Nitronome has more area coverage and speed in movement and charge time, though a little less damage than Big Angry and Irontech against a single target per bomb. Big Angry takes a different approach, giving up basically everything except damage and knockback for a little more damage per hit on a single target (blast radius is shorter, less area coverage to damage) and hilarious knockback to blast targets to Russia. The shorter radius and longer fuse time are to prevent abuse of the knockback. Apparently having a slight damage per hit advantage contributes rather than allowing more rapid assaults.
Catalyzer
Yes.
Magnus lines
Similar to Plate and Troika lines, Magnus is supposed to be tank-esque; solid, skull splitting smashes of squishing. Boolit shoot good. Magnus lines in general should have significant attack interruption.
Pulsar
Changing its clip to two shots would also contribute.
Cautery
Matching its damage to Calibur line may be pushing it seeing as it would have a massive family bonus, a bonus which is necessary for the weapon to stay consistent.
Omega
This shield is supposed to be the melee tanking shield. I also have something for this item though giving it multiple defenses would turn it into the ultimate general use shield.
Seerus bombs
They halved speed and damage when they nerfed these. The original speed caused significant lag if three or more of these were set at once, but giving some of its speed back would make it more useful again.
Plague and Pepperbox lines
Plague is more support reliant while Pepperbox depends entirely on strategic use.
Antigua lines
They are meant to be counterparts, not independent of each other.
Volcanic has lots of normal defense. Omega shell has lots of health.