My vote
Perk: Deadly Slash II
Trinket 2: Elite Boom Module
Trinket 1: Elite Bomb Focus Module
Helmet: Mad Bomber Mask
Armor: Mad Bomber Suit
Shield: Barbarous Thorn Shield
Weapon 1: Polaris
Weapon 2: Volcanic Pepperbox
Weapon 3: Sentenza
Weapon 4: Plague Needle
What about you?
Perk: Deadly Slash II
Trinket 1: True Love Locket
Trinket 2: True Love Locket
Helmet: Chaos
Armour: Chaos
Shield: Crest of Almire
Weapon 1-3: Acheron
Weapon 4: Blitz
/thread
In all seriousness there may be best loadouts but if really depends on how you play. I may use chaos but I have used it pre-buff as well as I played a hybrid knight. It comes down to if you want to be effective or have fun, as the most effective weapons are not always that interesting. Using a brandish may be the "best" but slashing through a crowd of monsters in my EV with a DVS is arguably a lot more fun.