I think we have a problem with the way we gain items, and the way we loose or spend them. We gain them plenty while we're roaming the depths, but we have no real way to spend or lose them? Sure we have alchemy, but we can't possibly spend all our materials on that? I personally have an incredibly amount of materials that I find no use for. That doesn't feel right. When I try to put them to use by crafting another set of gear, I just find myself having extra gear that I can't quite put to good use either. I can't lose gear, so I'll just have it sitting in my inventory, waiting for me to wear it occasionally when I'm in the mood for it.
What do to with it?
If alchemy costs were cheaper, I'd suggest crafting many copies to get good unique variants.
But that gets expensive fast.