1. Does MSI make a striker dash have a faster speed? (or more distance)
2. Does MSI make a hammer dash go a further distance?
3. Does dmg boost matter much in lockdown? eg. ASI max w/ no dmg boost vs no asi w/ max dmg (or something more in between)
4. Is it better to have lower dmg and higher asi than lower asi and higher dmg? Because I'd like to know if it's worth sacrificing dmg for other resistances/hp/utility.
1- MSI makes striker boost faster yet doesn't use more fuel, thus letting you travel faster and further. It makes a difference at dodging and catching others, but it is not much of a gamebreaker.
2- As far as I know, MSI doesn't affect the hammer dash, and if it does, it would have the exact same function as ASI, letting you finalize the dash faster.
3- Maximum damage will reduce the required number of hits to kill by at least one, while higher ASI will give you an upper hand in 1v1 duels. ASI is also better at making slow swords and brandishes more viable. Rich people get maximum ASI Acherons and make poor people cry. On the other hand, most of the LD community use double penta heart pendants, which makes damage bonus necessary for survival.
Since striker boost already has enough ASI and you need more than 14% damage bonus, I would prioritize damage over ASI.
4- That's the same question as the third. Although status resistances are nice to have, mist bombers and alchemer switchers are not the worst of your problems, instead of being strong against a specific class, you should go for other bonuses which help you against everything- higher damage bonus means that if that mist bomber is going down, it is going to go down faster. Higher ASI means you can dive in and land a hit or two on that gunner who flies like a butterfly and shoots bees.
HP is a little more tricky... Having HP trinkets means you can eliminate the one casualty for strikers which is having significantly less health. Save your trinkets for HP and get damage bonus from your armor.